PerioGlas® References

»In Vivo Studies»Human Studies

Giusto TJ. Bioactive glass and bioabsorbable membrane in the treatment of a maxillary class II furcation defect: case report with 6-month re-entry. Compend Contin Educ Dent. 2005 Jan;26(1):41-2, 44, 46 passim; quiz 52-3.
Sculean A, Barbe G, Chiantella GC, Arweiler NB, Berakdar M, Brecx M. Clinical evaluation of an enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans. J Periodontol. 2002 Apr;73(4):401-8
Han J, Meng H, Xu Li, Chou L Anti-inflammatory Effect of Bioactive Glass On Human Periodontal Intrabony Defects. 2002
Park JS, Suh JJ, Choi SH, Moon IS, Cho KS, Kim CK, Chai JK. Effects of pretreatment clinical parameters on bioactive glass implantation in intrabony periodontal defects. J Periodontol. 2001 Jun;72(6):730-40
Yukna RA, Evans GH, Aichelmann-Reidy MB, Mayer ET. Clinical comparison of bioactive glass bone replacement graft material and expanded polytetrafluoroethylene barrier membrane in treating human mandibular molar class II furcations. J Periodontol. 2001 Feb;72(2):125-33
Norton MR, Wilson J. Bone Augmentation with Bioactive Ceramics before Insertion of Endosseous Dental Implants:  Histories and Human Histology on Seventeen Consecutive Cases. Key Engineering Materials. Vols 192-195 (2001) pp 869-872.
Xynos ID, Edgar AJ, Buttery LD, Hench LL, Polak JM. Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution. J Biomed Mater Res. 2001 May;55(2):151-7
Barbé G, Sculean A, Chiantella GC. Vertical Reconstruction of Horizontal Periodontal Defects Using a Bioactive Glass. Journal de parodontologie & d'implantologie orale. 2000 20(1):51-60.
Anderegg CR, Alexander DC, Freidman M. A bioactive glass particulate in the treatment of molar furcation invasions. J Periodontol. 1999 Apr;70(4):384-7
Kinnunen I, Aitasalo K, Pollonen M, Varpula M. Reconstruction of orbital floor fractures using bioactive glass. J Craniomaxillofac Surg. 2000 Aug;28(4):229-34
Lovelace TB, Mellonig JT, Meffert RM, Jones AA, Nummikoski PV, Cochran DL. Clinical evaluation of bioactive glass in the treatment of periodontal osseous defects in humans. J Periodontol. 1998 Sep;69(9):1027-35
Froum SJ, Weinberg MA, Tarnow D. Comparison of bioactive glass synthetic bone graft particles and open debridement in the treatment of human periodontal defects. A clinical study. J Periodontol. 1998 Jun;69(6):698-709
Kates JJ, Greskovich MS, Smith WK, Ariel DR, Diamond MW. Long-Term Evaluation of the Use of PerioGlas in Alveolar Ridge Augmentation Following Tooth Extraction:  A Prospective Human Study. Dental Cadmos, 1998.
Low SB, King CJ, Krieger J. An evaluation of bioactive ceramic in the treatment of periodontal osseous defects. Int J Periodontics Restorative Dent. 1997 Aug;17(4):358-67.
Aitasalo K, Suonpää J, Peltola M, Yli-Urpo A. Behavior of Bioactive Glass (S53P4) in Human Frontal Sinus Obliteration. Bioceramics, Vol 10, pg 429-432, Oct 1997.
Shapoff CA, Alexander DC, Clark AE. Clinical use of a bioactive glass particulate in the treatment of human osseous defects. Compend Contin Educ Dent. 1997 Apr;18(4):352-4, 356, 358 passim
Zamet JS, Darbar UR, Griffiths GS, Bulman JS, Bragger U, Burgin W, Newman HN. Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects. J Clin Periodontol. 1997 Jun;24(6):410-8


»In Vivo Studies»Animal Studies

Yuan H, de Bruijn JD, Zhang X, van Blitterswijk CA, de Groot K. Bone induction by porous glass ceramic made from Bioglass (45S5). J Biomed Mater Res. 2001 May 1;58(3):270-6.
Wheeler DL, Eschbach EJ, Hoellrich RG, Montfort MJ, Chamberland DL. Assessment of resorbable bioactive material for grafting of critical-size cancellous defects. J Orthop Res. 2000 Jan;18(1):140-8
Bergman SA, Litkowski LJ. Bone In-Fill of Non-Healing Calvarial Defects Using Particulate Bioglass® and Autogenous Bone. In Bioceramics: Volume 8, J Wilson, LL Hench, and D Greenspan eds., Elsevier Science, Ltd., Oxford, 1995, 17-21.
Oonishi H, Hench LL, Wilson J, Sugihara F, Tsuji E, Matsuura M, Kin S, Yamamoto T, Mizokawa S. Quantitative comparison of bone growth behavior in granules of Bioglass, A-W glass-ceramic, and hydroxyapatite. J Biomed Mater Res. 2000 Jul;51(1):37-46
Oonishi H, Hench LL, Wilson J, Sugihara F, Tsuji E, Kushitani S, Iwaki H. Comparative bone growth behavior in granules of bioceramic materials of various sizes. J Biomed Mater Res. 1999 Jan;44(1):31-43
Wheeler DL, Stokes KE, Hoellrich RG, Chamberland DL, McLoughlin SW. Effect of bioactive glass particle size on osseous regeneration of cancellous defects. J Biomed Mater Res. 1998 Sep 15;41(4):527-33. 
Oonishi H, Kushitani S, Yasukawa E, Iwaki H, Hench LL, Wilson J, Tsuji E, Sugihara T. Particulate bioglass compared with hydroxyapatite as a bone graft substitute. Clin Orthop. 1997 Jan;(334):316-25
Fujishiro Y, Hench LL, Oonishi H. Quantitative rates of in vivo bone generation for Bioglass® and hydrosyapatite particles as bone graft substitute. J of Materials Science: Materials in Medicine 8. (1997) 649-652
Johnson MW, Sullivan SM, Rohrer M, Collier M. Regeneration of peri-implant infrabony defects using PerioGlas: a pilot study in rabbits. J Biomed Mater Res. 1999 Aug;46(2):301-4.


»In Vitro Studies

Leonor IB, Ito A, Onuma K, Kanzaki N, Zhong JP, Greenspan D, Reis RL. In situ study of partially crystallized Bioglass and hydroxyapatite in vitro bioactivity using atomic force microscopy.  J Biomed Mater Res. 2002, 62: 82-8.
Allan L, Newman H, Wilson M. Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model. Clin Oral Implants Res. 2002 Feb;13(1):53-8

Loty C, Sautier JM, Tan MT, Oboeuf M, Jallot E, Boulekbache H, Greenspan D, Forest N. Bioactive glass stimulates in vitro osteoblast differentiation and creates a favorable template for bone tissue formation.  J Bone Miner Res. 2001 Feb;16(2):231-9
Allan I, Newman H, Wilson M. Antibacterial activity of particulate bioglass against supra- and subgingival bacteria. Biomaterials. 2001 Jun;22(12):1683-7.

Greenspan DC, Zhong JP, LaTorre GP. The Evaluation of Surface Structure of Bioactive Glasses In Vitro. In Bioceramics: Volume 8, J Wilson, LL Hench, and D Greenspan eds., Elsevier Science, Ltd., Oxford, 1995, 477-82.
Xynos ID, Edgar AJ, Buttery LD, Hench LL, Polak JM. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem Biophys Res Commun. 2000 Sep 24;276(2):461-5.
Xynos ID, Hukkanen MV, Batten JJ, Buttery LD, Hench LL, Polak JM. Bioglass 45S5 stimulates osteoblast turnover and enhances bone formation In vitro: implications and applications for bone tissue engineering. Calcif Tissue Int. 2000 Oct;67(4):321-9
Price N, Bendall SP, Frondoza C, Jinnah RH, Hungerford DS. Human osteoblast-like cells (MG63) proliferate on a bioactive glass surface. J Biomed Mater Res. 1997 Dec 5;37(3):394-400.

Vrouwenvelder WC, Groot CG, de Groot K. Histological and biochemical evaluation of osteoblasts cultured on bioactive glass, hydroxyapatite, titanium alloy, and stainless steel. J Biomed Mater Res. 1993 Apr;27(4):465-75

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