References (Click on reference to view abstract)

    In Vitro Studies

1. Evaluation of the interactions between collagen and the surface of a bioactive glass during in vitro test.

2. Microarray-based gene expression analysis of human osteoblasts in response to different biomaterials.

3. Proangiogenic Potential of a Collagen/Bioactive Glass Substrate.

4. Antimicrobial effect of nanometric bioactive glass 45S5.

5. Bactericidal effects of bioactive glasses on clinically important aerobic bacteria.

6. Do bioactive glasses convey a disinfecting mechanism beyond a mere increase in pH?

7. Genetic portrait of osteoblast-like cells cultured on Bioactive Glass.

    In Vivo studies

Animal

1. Cranial defect reconstruction in an experimental model using different mixtures of Bioglass and autologous bone.

2. Bioactive glass-derived hydroxyapatite-coating promotes granulation tissue growth in subcutaneous cellulose implants in rats

3. Use of bioglass for orbital volume augmentation in enophthalmos: a rabbit model (oryctolagus cuniculus)

4. Bioactive glass ceramic particles as an alternative to mastoid obliteration: results in an animal model.

5. Bone healing in osteoporotic female rats following intra-alveolar grafting of bioactive glass.

    

Human

1. Bioactive glass as a bone substitute for spinal fusion in adolescent idiopathic scoliosis: a comparative study with iliac crest autograft.

2. Bioactive glass hydroxyapatite in fronto-orbital defect reconstruction.

3. Clinical and histologic comparison of two different composite grafts for sinus augmentation: a pilot clinical trial

4. Effect of soft laser and bioactive glass on bone regeneration in the treatment of infra-bony defects (a clinical study).

 

 

 

NovaBone Putty has been used  in  Orthopedic cases from 2006 and in dental surgeries since Sept 2007. Although the active ingredient, Bioactive Glass has been used as a bone graft material for over 13 years with over 1 Million clinical applications. 

 

  In Vitro Studies

  In Vivo Studies

Animal

Human