References (Click on reference to view abstract)

Basic Science of Bioactive Glass

1. Bioactive Glasses and Glass-Ceramics:  A 25 Year Retrospective.

2. Bioactive Glasses:  Present and Future.

3. Third-generation biomedical materials.

    In Vitro Studies

1. Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model.

2. Bioactive glass stimulates in vitro osteoblast differentiation and creates a favorable template for bone tissue formation.

3. Antibacterial activity of particulate bioglass against supra- and subgingival bacteria.

4. In situ study of partially crystallized Bioglass and hydroxyapatite in vitro bioactivity using atomic force microscopy.

5. The Evaluation of Surface Structure of Bioactive Glasses In Vitro

6. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.

7. Bioglass 45S5 stimulates osteoblast turnover and enhances bone formation In vitro: implications and applications for bone tissue engineering.

8. Human osteoblast-like cells (MG63) proliferate on a bioactive glass surface.

9. Histological and biochemical evaluation of osteoblasts cultured on bioactive glass, hydroxyapatite, titanium alloy, and stainless steel.

    In Vivo studies

Animal

1. Bone induction by porous glass ceramic made from Bioglass (45S5).

2. Assessment of resorbable bioactive material for grafting of critical-size cancellous defects.

3. Bone In-Fill of Non-Healing Calvarial Defects Using Particulate Bioglass® and Autogenous Bone.

4. Quantitative comparison of bone growth behavior in granules of Bioglass, A-W glass-ceramic, and hydroxyapatite.

5. Comparative bone growth behavior in granules of bioceramic materials of various sizes.

6. Effect of bioactive glass particle size on osseous regeneration of cancellous defects.

7. Particulate bioglass compared with hydroxyapatite as a bone graft substitute.

8. Quantitative rates of in vivo bone generation for Bioglass® and hydrosyapatite particles as bone graft substitute.

9. Regeneration of peri-implant infrabony defects using PerioGlas: a pilot study in rabbits.

Human

1. Bioactive glass and bioabsorbable membrane in the treatment of a maxillary class II furcation defect: case report with 6-month re-entry.

2. Clinical evaluation of an enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans.

3. Anti-inflammatory Effect of Bioactive Glass On Human Periodontal Intrabony Defects.

4. Effects of pretreatment clinical parameters on bioactive glass implantation in intrabony periodontal defects.

5. Clinical comparison of bioactive glass bone replacement graft material and expanded polytetrafluoroethylene barrier membrane in treating human mandibular molar class II furcations.

6. Bone Augmentation with Bioactive Ceramics before Insertion of Endosseous Dental Implants:  Histories and Human Histology on Seventeen Consecutive Cases.

7. Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution.

8. Vertical Reconstruction of Horizontal Periodontal Defects Using a Bioactive Glass

9. A bioactive glass particulate in the treatment of molar furcation invasions.

10. Reconstruction of orbital floor fractures using bioactive glass.

11. Clinical evaluation of bioactive glass in the treatment of periodontal osseous defects in humans.

12. Comparison of bioactive glass synthetic bone graft particles and open debridement in the treatment of human periodontal defects. A clinical study.

13. Long-Term Evaluation of the Use of PerioGlas in Alveolar Ridge Augmentation Following Tooth Extraction:  A Prospective Human Study.

14. An evaluation of bioactive ceramic in the treatment of periodontal osseous defects.

15. Behavior of Bioactive Glass (S53P4) in Human Frontal Sinus Obliteration.

16. Clinical use of a bioactive glass particulate in the treatment of human osseous defects.

17. Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects.

 

 

 

 

 

 

 

 

Bioactive Glass has been used as a bone graft material for over a 13 years. It has been used in about 850,000 medical/dental applications.  Several clinical articles have demonstrated its long standing record of safety and efficacy.

  Basic Science

  In Vitro Studies

  In Vivo Studies

Animal

Human

 

 

 

 

 

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